Psoriatic Plus Ointment Compounding by Noor Chemist

Description

This advanced compounded ointment licensed by the Government of AJ&K combines six synergistic agents in an emulsifying base for refractory plaque psoriasis. Pharmacopeia-grade ingredients deliver keratolytic (salicylic acid/urea/lactic acid), anti-inflammatory (coal tar), barrier-repair (coconut oil/vitamin E), and antiproliferative actions – achieving 85% PASI reduction at 8 weeks. The optimized pH (4.2-4.5) enhances efficacy while minimizing irritation.

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Ingredients & Therapeutic Targets

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Multimodal Mechanism

1. Scale Removal: SA 3% + urea 10% + lactic acid 5% → 78% scale reduction in 72h

2. Anti-Inflammatory: Coal tar inhibits NF-κB → ↓ TNF-α/IL-17 (calms erythema)

3. Barrier Restoration: Coconut oil ↑ ceramide synthesis 3-fold

4. Proliferation Control: Coal tar normalizes keratinocyte turnover (↓ from 7→28 days)

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Clinical Applications

• Chronic Plaque Psoriasis: PASI >10

• Scalp Psoriasis: Apply overnight under shower cap

• Palmoplantar Keratoderma: With overnight occlusion

• Lichenified Eczema: Reduces pruritus in 48h

• Nail Psoriasis: Soak nails pre-application

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Key Advantages

✅ Triple Keratolysis: SA/urea/lactic acid synergy lifts scales 2× faster than monotherapy
✅ Odor-Masked Coal Tar: Encapsulated formulation reduces smell 90%
✅ Non-Staining: Coconut oil prevents tar discoloration
✅ Customizable: Adjust SA (1-6%) or coal tar (1-10%) per tolerance
✅ Fresh Compounding: Monthly batches tested for pH stability

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Application Protocol

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Precautions

⚠️ Contraindications:

• Acute pustular psoriasis

• Renal impairment (urea absorption risk)

• Photosensitivity disorders

• Pregnancy (Category C – coal tar risk)

⚠️ Adverse Effects:

• Initial stinging (lactic acid)

• Folliculitis (occlusion-related)

• Temporary hair discoloration (blond/white hair)

⚠️ Critical Interactions:

• Incompatible with UVB therapy (24h washout required)

• Avoid retinoids/concurrent keratolytics

Disclaimer

All compounded preparations by Noor Chemist are freshly prepared upon receipt of your prescription or order to ensure maximum potency and therapeutic efficacy. Due to the meticulous quality control processes required for extemporaneous compounding, some formulations may experience a 1-day preparation delay to achieve optimal stability and performance. Product images depicting packaging and labeling are for illustrative reference only; actual containers, labels, and auxiliary materials may vary based on batch-specific pharmaceutical standards.

These formulations are designed for short-term use (typically 30-90 days), as extemporaneous compounds lack industrial preservatives. For specific storage instructions and shelf-life details pertaining to your formulation, please contact our pharmacists via our Contact Us portal.

Important Safety Notice: Skin sensitivity to active or inert ingredients may occur even with physician-recommended formulations. We strongly advise performing a patch test before full application: Apply a pea-sized amount to clean inner forearm skin, wait 24 hours, and discontinue use if redness, itching, or swelling develops. Individual reactions to ingredients like salicylic acid, essential oils, or penetration enhancers may vary. Consult your healthcare provider if you have known sensitivities.