Name: GTN Plus Compounding by Noor Chemist
SKU: 10294
Availability: InStock

GTN Plus Compounding by Noor Chemist

₨ 390

GTN 0.3% + lidocaine 3% ointment
Anorectal/vaginal muscle relaxant + anesthetic
Chronic fissure/vulvodynia therapy
AJK-licensed compounding

Size and packaging guidelines

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Specification	Chair	Armchair	Sofas
Height	37"	42"	42"
Width	26.5"	32.5"	142"
Depth	19.5"	22.5"	24.5"
Assembly Required	No	No	Yes
Packaging Type	Box	Box	Box
Package Weight	55 lbs.	64 lbs.	180 lbs.
Packaging Dimensions	27" x 26" x 39"	45" x 35" x 24"	46" x 142" x 25"

Description

This dual-action compounded formulation licensed by the Government of AJ&K combines glyceryl trinitrate (GTN) with lidocaine for sphincter hypertonia and pain management. GTN’s nitric oxide donation reduces anal/vaginal resting pressure by 35%, while lidocaine provides rapid mucosal anesthesia. Pharmacopeia-grade preparation ensures targeted delivery without first-pass metabolism. Indicated for chronic anal fissures, vulvodynia, and post-surgical spasms.

Ingredients & Mechanisms

Component	Concentration	Role & Clinical Action
Glyceryl Trinitrate	0.3%	Smooth muscle relaxant: Converts to NO → cGMP-mediated relaxation
Lidocaine HCl	3%	Anesthetic: Blocks voltage-gated Na⁺ channels (onset: 90 sec)
Base	Anhydrous PEG	Water-soluble; enhances mucosal penetration

Primary Indications

Chronic anal fissures (>4 weeks)
Vestibulodynia/vulvar pain syndromes
Post-episiotomy/hemorrhoidectomy spasms
Pelvic floor hypertonia

Therapeutic Advantages

✅ Synergistic Effect: GTN resolves spasm + lidocaine enables painless application
✅ Avoids Surgery: 85% acute fissure healing rate at 6 weeks
✅ Non-Systemic: Plasma GTN <0.2 ng/mL (vs. 5 ng/mL sublingual)
✅ Stability: PEG base prevents GTN degradation (98% potency at 6 months)
✅ Customizable: GTN 0.1%-0.4% strengths available

Application Protocol

Condition	Method	Frequency	Max Duration
Anal Fissure	Apply 0.5″ ribbon intra-anally	BID	8 weeks
Vulvodynia	Apply to vestibule with cotton swab	TID	12 weeks
Post-Op Spasm	Apply to surgical site pre-defecation	PRN	2 weeks

Critical Precautions

⚠️ Contraindications:

Concomitant PDE5 inhibitors (sildenafil/tadalafil)
Severe anemia
Hypotension (SBP <90 mmHg)
Lidocaine allergy

⚠️ Adverse Effects:

Headache (30% patients; usually transient)
Local burning (5%)
Reflex tachycardia (rare)

⚠️ Pregnancy: Category B (avoid large mucosal areas)

Disclaimer

All compounded preparations by Noor Chemist are freshly prepared upon receipt of your prescription or order to ensure maximum potency and therapeutic efficacy. Due to the meticulous quality control processes required for extemporaneous compounding, some formulations may experience a 1-day preparation delay to achieve optimal stability and performance. Product images depicting packaging and labeling are for illustrative reference only; actual containers, labels, and auxiliary materials may vary based on batch-specific pharmaceutical standards.

These formulations are designed for short-term use (typically 30-90 days), as extemporaneous compounds lack industrial preservatives. For specific storage instructions and shelf-life details pertaining to your formulation, please contact our pharmacists via our Contact Us portal.

Important Safety Notice: Skin sensitivity to active or inert ingredients may occur even with physician-recommended formulations. We strongly advise performing a patch test before full application: Apply a pea-sized amount to clean inner forearm skin, wait 24 hours, and discontinue use if redness, itching, or swelling develops. Individual reactions to ingredients like salicylic acid, essential oils, or penetration enhancers may vary. Consult your healthcare provider if you have known sensitivities.