20% Urea Cream Compounding by Noor Chemist

Description

This pharmacopeia-grade compounded cream licensed by the Government of AJ&K delivers 20% analytical urea in a stabilized aqueous cream base for severe hyperkeratotic conditions. Urea disrupts hydrogen bonds in keratin, reducing stratum corneum thickness by 60% while binding 3× its weight in water for sustained hydration. Clinically validated for plantar fissures, ichthyosis, and psoriatic plaques where lower concentrations (≤10%) fail.

Ingredients & Mechanisms

Primary Therapeutic Actions

• Fissure Healing: Softens hyperkeratotic edges in 72h

• Scale Removal: 78% reduction in psoriatic/ichthyotic scales

• Drug Penetration: Enhances absorption of topical steroids/antifungals 3-fold

• Callus Management: Debulks plantar calluses in 14 days

• Nail Softening: Prepares thickened nails for debridement

Key Clinical Applications

Advantages Over Lower Concentrations

✅ High-Efficacy Keratolysis: 20% dissolves keratin bonds 3× faster than 10% urea
✅ Pain Relief: Reduces fissure pain by VAS 7→2 in 48h
✅ Barrier Repair: Upregulates filaggrin synthesis (↑ natural moisturizing factors)
✅ Non-Irritating: pH-balanced formula avoids stinging
✅ Cost-Effective: 50% cheaper per mg urea than commercial brands

Application Protocol

Precautions

⚠️ Contraindications:

• Deep ulcers/exudative wounds

• Urea metabolism disorders

• Children <2 years (systemic absorption risk)
  ⚠️ Adverse Effects:

• Transient stinging (5% patients)

• Avoid face/genitals (mucosal irritation)
  ⚠️ Interactions:

• Incompatible with silver dressings (forms complexes)

Disclaimer

All compounded preparations by Noor Chemist are freshly prepared upon receipt of your prescription or order to ensure maximum potency and therapeutic efficacy. Due to the meticulous quality control processes required for extemporaneous compounding, some formulations may experience a 1-day preparation delay to achieve optimal stability and performance. Product images depicting packaging and labeling are for illustrative reference only; actual containers, labels, and auxiliary materials may vary based on batch-specific pharmaceutical standards.

These formulations are designed for short-term use (typically 30-90 days), as extemporaneous compounds lack industrial preservatives. For specific storage instructions and shelf-life details pertaining to your formulation, please contact our pharmacists via our Contact Us portal.

Important Safety Notice: Skin sensitivity to active or inert ingredients may occur even with physician-recommended formulations. We strongly advise performing a patch test before full application: Apply a pea-sized amount to clean inner forearm skin, wait 24 hours, and discontinue use if redness, itching, or swelling develops. Individual reactions to ingredients like salicylic acid, essential oils, or penetration enhancers may vary. Consult your healthcare provider if you have known sensitivities.