20% Monobenzone Cream Compounding by Noor Chemist

Description

This high-potency compounded cream licensed by the Government of AJ&K contains monobenzone 20% – a phenolic ether that permanently inhibits melanin synthesis through selective melanocyte cytotoxicity. Reserved for definitive depigmentation therapy in extensive vitiligo (>80% BSA involvement) when repigmentation fails. The lipophilic base ensures epidermal penetration without systemic absorption. Not for cosmetic hyperpigmentation disorders.

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Mechanism & Clinical Action

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Primary Indications

• Extensive Vitiligo: Universal depigmentation goal (>80% BSA)

• Refractory Vitiligo: After failure of PUVA/topical steroids

• Symmetric Depigmentation: In patients opting for uniform skin tone

(Note: Strictly contraindicated for melasma/post-inflammatory hyperpigmentation)

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Critical Usage Protocol

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Absolute Precautions

⚠️ Permanent Effects:

• Irreversible depigmentation

• Hypersensitivity to sun (lifetime SPF 50+ mandatory)

• “Confetti” depigmentation on adjacent skin

⚠️ Contraindications:

• Localized vitiligo (<50% BSA)

• Dark skin types (Fitzpatrick V-VI) – risk of disfiguring contrast

• Pregnancy/lactation (Category X)

• Children <18 years

⚠️ Adverse Effects:

• Contact dermatitis (40%)

• Koebner phenomenon (new vitiligo at trauma sites)

• Ocular toxicity (avoid periocular use)

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Therapeutic Realities

✅ Permanent Solution: Only FDA-recognized depigmentation agent
✅ Progressive Effect: Depigmentation continues post-treatment
✅ No Alternatives: For patients rejecting camouflage/repigmentation
✖️ Not Reversible: Melanocyte destruction is irreversible

Disclaimer

All compounded preparations by Noor Chemist are freshly prepared upon receipt of your prescription or order to ensure maximum potency and therapeutic efficacy. Due to the meticulous quality control processes required for extemporaneous compounding, some formulations may experience a 1-day preparation delay to achieve optimal stability and performance. Product images depicting packaging and labeling are for illustrative reference only; actual containers, labels, and auxiliary materials may vary based on batch-specific pharmaceutical standards.

These formulations are designed for short-term use (typically 30-90 days), as extemporaneous compounds lack industrial preservatives. For specific storage instructions and shelf-life details pertaining to your formulation, please contact our pharmacists via our Contact Us portal.

Important Safety Notice: Skin sensitivity to active or inert ingredients may occur even with physician-recommended formulations. We strongly advise performing a patch test before full application: Apply a pea-sized amount to clean inner forearm skin, wait 24 hours, and discontinue use if redness, itching, or swelling develops. Individual reactions to ingredients like salicylic acid, essential oils, or penetration enhancers may vary. Consult your healthcare provider if you have known sensitivities.