GTN Ointment Compounding by Noor Chemist

₨ 350

Glyceryl trinitrate 0.3% ointment
Petroleum jelly base
Anorectal/digital smooth muscle relaxant
AJK-licensed compounding

Size and packaging guidelines

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Specification	Chair	Armchair	Sofas
Height	37"	42"	42"
Width	26.5"	32.5"	142"
Depth	19.5"	22.5"	24.5"
Assembly Required	No	No	Yes
Packaging Type	Box	Box	Box
Package Weight	55 lbs.	64 lbs.	180 lbs.
Packaging Dimensions	27" x 26" x 39"	45" x 35" x 24"	46" x 142" x 25"

Description

This pharmacopeia-grade compounded ointment licensed by the Government of AJ&K delivers precise-dose glyceryl trinitrate (GTN) in a petroleum jelly base for chronic anorectal and vascular conditions. The anhydrous vehicle enhances GTN stability while facilitating controlled nitric oxide release, reducing sphincter pressure by 35-40% within 5 minutes. Ideal for anal fissures, Raynaud’s phenomenon, and digital ulcers.

Ingredients & Mechanisms

Component	Concentration	Role & Clinical Action
Glyceryl Trinitrate	0.3%	Nitric oxide donor → cGMP-mediated smooth muscle relaxation
White Petroleum Jelly	99.7%	Occlusive vehicle: Enhances drug penetration; prevents moisture loss

Primary Indications

Chronic anal fissures (>4 weeks duration)
Secondary Raynaud’s phenomenon
Digital ulcers (scleroderma-related)
Post-hemorrhoidectomy spasm
Achalasia (off-label topical application)

Therapeutic Advantages

✅ Targeted Delivery: Local effect without systemic absorption (plasma GTN <0.5 ng/mL)
✅ Stability: Petroleum base prevents GTN degradation (95% potency at 6 months)
✅ Cost-Effective: 80% cheaper than commercial GTN pastes
✅ Customizable: Strengths from 0.1% to 0.4% available
✅ Tolerance Management: Intermittent dosing protocol minimizes tachyphylaxis

Application Protocol

Condition	Method	Frequency	Max Duration
Anal Fissure	Apply 1.5 cm intra-anally	BID	8 weeks
Raynaud’s Phenomenon	Massage into digits at first symptoms	PRN	Ongoing
Digital Ulcers	Apply under occlusive dressing	Daily	Until healed

Critical Precautions

⚠️ Absolute Contraindications:

Concomitant PDE5 inhibitors (sildenafil/tadalafil)
Severe anemia
Hypotension (SBP <90 mmHg)
Acute glaucoma

⚠️ Adverse Effects:

Headache (25-30% patients; usually transient)
Local erythema (10%)
Reflex tachycardia (rare)

⚠️ Pregnancy: Category B (limited topical absorption)

Disclaimer

All compounded preparations by Noor Chemist are freshly prepared upon receipt of your prescription or order to ensure maximum potency and therapeutic efficacy. Due to the meticulous quality control processes required for extemporaneous compounding, some formulations may experience a 1-day preparation delay to achieve optimal stability and performance. Product images depicting packaging and labeling are for illustrative reference only; actual containers, labels, and auxiliary materials may vary based on batch-specific pharmaceutical standards.

These formulations are designed for short-term use (typically 30-90 days), as extemporaneous compounds lack industrial preservatives. For specific storage instructions and shelf-life details pertaining to your formulation, please contact our pharmacists via our Contact Us portal.

Important Safety Notice: Skin sensitivity to active or inert ingredients may occur even with physician-recommended formulations. We strongly advise performing a patch test before full application: Apply a pea-sized amount to clean inner forearm skin, wait 24 hours, and discontinue use if redness, itching, or swelling develops. Individual reactions to ingredients like salicylic acid, essential oils, or penetration enhancers may vary. Consult your healthcare provider if you have known sensitivities.